The crossbreeding, very popular practice in the last century, tries to obtain a new variety starting from two different vines, with the aim of infusing the respective qualities in the crossed plant.

In 1882, the Swiss Hermann Müller created the Müller Thurgau with vines of Riesling Renano and Madeleine Royale (although he thought it was Silvaner). Today this vine is enhance within several designations, including Trentino Müller Thurgau DOC and Alto Adige Müller Thurgau DOC.

In 1929, the German August Herold made the Kerner crossbreed (the name derives from Justinus Kerner, an author who wrote poetry about wine), crossing Schiava Grigia and Riesling. Today it is protected in the designation Alto Adige Kerner DOC.

In the first half of the last century, Luigi Manzoni from Veneto was very active in searching for new vine varieties, identifying with good results various crossbreedings: the best known is the Manzoni Bianco (also called Manzoni 6.0.13), obtained by Riesling Renano and Pinot Bianco.

In 1936, Bruno Bruni from Marche realized the Bruni crossbreed (coded Bruni 54), starting from Sauvignon Blanc and Verdicchio.

In 1948, Rebo Rigotti from Trentino created the Rebo crossbreed between Merlot and Teroldego (actually convinced that it was Marzemino). This vine is today enhanced in the denomination Trentino Rebo DOC.

In the middle of the century, Riccardo Terzi from Lombardy realized the Terzi crossbreed (codified Terzi 1) from Barbera and Cabernet Franc vines.